c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia
نویسندگان
چکیده
By analysis of a series of somatic cell hybrids derived by fusion of either mouse or Chinese hamster cells with leukocytes from different chronic myelocytic leukemia (CML) patients or from normal donors, we have localized the human oncogene, c-sis, on the q11 to qter segment of chromosome 22 and demonstrated its translocation from chromosome 22 to chromosome 9 (q34) in CML.
منابع مشابه
C-sis and C-abl expression in chronic myelogenous leukemia and other hematologic malignancies.
Cellular oncogenes have been localized at the breakpoints of characteristic chromosomal rearrangements occurring in certain hematologic malignancies. This has been reported to result in aberrant expression of the involved oncogenes. Over 90% of chronic myelogenous leukemia (CML) is characterized by a reciprocal translocation that brings c-abl from chromosome 9 to chromosome 22, and c-sis from c...
متن کاملLocalization of the human c-sis oncogene in Ph1-positive and Ph1-negative chronic myelocytic leukemia by in situ hybridization.
Oncogenes are a group of evolutionary conserved cellular genes (c-onc) homologous to the transforming genes of oncogenic retroviruses (v-onc). Some of them are localized near the breakpoints of specific chromosomal aberrations occurring in various neoplasms, as for example the Philadelphia translocation, t(9;22)(q34;q11), in chronic myelocytic leukemia (CML). Recently, we localized the human c-...
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The Philadelphia (Ph) chromosome, the product of t(9:22), is the cytogenetic hallmark of chronic myelogenous leukemia. The c-abl oncogene on chromosome 9 is translocated to the Ph chromosome and linked to a breakpoint cluster region (bcr), which is part of a large bcr gene. This results in the formation of a bcr-c-abl fusion gene, which is transcribed into an 8.5 kb chimeric mRNA encoding a 210...
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C HRONIC MYELOGENOUS LEUKEMIA (CML) is characterized by two major phases. The chronic phase lasts an average of 3 years and is characterized primarily by accumulation of granulocytes and their precursors in the bone marrow and peripheral blood. This is followed by the acute phase (blast crisis) in which the leukemia cells fail to differentiate and to respond to regulatory factors of myelopoiesi...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 158 شماره
صفحات -
تاریخ انتشار 1983